Ergotioneina: principio activo de uso potencial en la industria agroalimentaria y médico-farmacéutica

Alberto Renato Inca-Torres, Anabell del Rocío Urbina-Salazar, Juan Bautista

Resumen


RESUMEN
La Ergotioneina (ERG) es un aminoácido soluble en agua. Es un fuerte y estable antioxidante.Tiene la capacidad de formar complejos con cationes metálicos, ayuda a prevenir la generación de ROS y protege las células del estrés oxidativo. La ERG ha recibido mucha atención como un agente terapéutico debido a sus propiedades químicas, se acumula en ciertos órganos donde se requiere su efecto, tiene posibles funciones fisiológicas como citoprotector con resultados exitosos in vitro y posibles in vivo al ser analizados sobre modelos animales. Actúa en la lesión pulmonar, disfunción hepatorenal y lesión por isquemia/reperfusión en el hígado y el intestino delgado y presenta posibles efectos beneficiosos en la salud vascular. Además, ERG ejerce un efecto protector contra las radiaciones UV, protege la piel de la oxidación y daño al ADN, y la membrana mitocondrial contra la oxidación. Gran parte del daño de la piel por la radiación UV está mediado por la generación de ROS. El objetivo de esta revisión fue profundizar en los conocimientos sobre los avances recientes de las propiedades de la ERG, su cuantificación y las principales propiedades que tiene este componente para ser utilizado como principio activo en la industria agroalimentaria y médico-farmacéutico debido a su función como posible agente terapéutico y potente antioxidante.

Palabras clave


Agaricus bisporus; antioxidante natural; citoprotector; estrés oxidativo; nutraceútico

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Referencias


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